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Patients allergic to sulfa may also be allergic to furosemide because of a similarity in the chemical structure of the medications. Furosemide should be avoided in kidney failure. Even though furosemide is important in treating excess fluid accumulation in patients with cirrhosis, sudden loss of fluid and electrolytes in these patients can worsen kidney function and even cause the patient to go into a coma. Furosemide can cause lowering of blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to heart rhythm abnormalities, especially in patients already taking digoxin (Lanoxin). Please visit the digoxin (Lanoxin) site for further information. Blood uric acid levels can increase during furosemide treatment, but precipitation of acute gout is rare. Furosemide may increase the toxic effect of aminoglycoside antibiotics on the ear, especially in patients with kidney dysfunction. Furosemide reduces the kidney excretion of lithium and can lead to lithium toxicity. Furosemide may impair kidney function when administered together with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Periodic blood tests are performed to monitor kidney function and electrolytes during treatment with furosemide. If you take one dose daily, take the missed dose as soon as you remember within 12 hours. If more than 12 hours have passed, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication. If you take more than one dose daily, take the missed dose up to 2 hours late. If more than 2 hours have passed, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

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